BackThe Shoemaker Protocol: A step-by-step guide to treating mold-related illness
If you've been sick for months or years with symptoms doctors can't explain, you're not imagining things. And you're not alone. Chronic exposure to water-damaged buildings can trigger a complex illness that affects multiple body systems. The Shoemaker Protocol offers a systematic path forward for those whose immune systems struggle to clear biotoxins.
The Shoemaker Protocol is a peer-reviewed treatment approach for mold-related illness. Developed over 30+ years with more than 14,000 patients, it works in three phases: Detox, Clear, and Repair. Most patients complete treatment in 6-12 months.
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What is the Shoemaker Protocol?
The Shoemaker Protocol is the leading peer-reviewed protocol designed to treat mold toxicity at the root cause. It was developed by Dr. Ritchie Shoemaker over 30+ years of clinical research with more than 14,000 patients. Unlike treatments that chase symptoms with medications, this protocol addresses why you're sick in the first place.
When you're exposed to a water-damaged building, your body takes in biotoxins from mold and other microbes. Most people's immune systems recognize and clear these toxins. But about 24% of the population carries HLA genes (HLA haplotypes) that make them unable to clear these toxins properly. The toxins recirculate through your body, triggering chronic inflammation that affects your brain, gut, hormones, and more.
Your body keeps recycling the same toxins because your immune system can't tag them for removal. The Shoemaker Protocol breaks this cycle by helping your body finally eliminate what it couldn't clear on its own.
The WHO has concluded that building dampness and mold cause respiratory symptoms, allergies, asthma, and immune system changes. Meta-analyses show home dampness or mold is associated with 30-50% increases in respiratory and asthma-related health outcomes. The NIEHS 2024 guidance document further recognizes that mold exposure can contribute to headaches, fatigue, cognitive difficulties, and mental health effects beyond the respiratory symptoms traditionally studied.
MoldCo's approach is guided by the Shoemaker Protocol. Our clinicians are trained in Dr. Shoemaker's methods and can guide you through each phase using a virtual-first, accessible platform.
The three phases of the Shoemaker Protocol
The protocol follows a specific sequence because each phase prepares your body for the next. Skipping phases sets you back.
Phase 1: Detox (binding and removing biotoxins)
The first goal is simple: stop the toxins from recirculating.
Your liver sends toxins to your digestive tract for elimination. But in mold-related illness, these toxins get reabsorbed and sent back through your body again. This loop keeps your immune system in constant overdrive.
Colesevelam (a prescription binder prescribed off-label for this use) breaks this cycle. It binds to biotoxins in your gut before they can be reabsorbed, allowing your body to eliminate them. Think of it like a molecular sponge that catches toxins on their way out. Instead of toxins going round and round, they finally leave your body.
This phase typically takes several weeks. Many people notice improvements within the first 8 weeks when following the protocol consistently.
One thing that surprises many patients: you can start this phase even while still in an environment with mold exposure. Finding a clean living space can take months. Starting treatment doesn't have to wait. Of course, removing yourself from exposure remains ideal for more complete improvement.
As one person shared after starting treatment:
"I am detoxing and having a healing crisis and all kinds of weird stuff is happening but its like I'm waking up and getting my brain back." — Reddit user
Phase 2: Clear (addressing MARCoNS and biofilms)
Once toxin levels drop, there's often another problem waiting: bacterial colonies living in your sinuses.
Up to 80% of patients with mold-related illness have MARCoNS (Multiple Antibiotic Resistant Coagulase Negative Staphylococci) colonizing their nasal passages. These bacteria form protective biofilms and produce substances that further suppress your immune system.
Even after binding and removing toxins, these bacterial colonies keep triggering inflammation. Your immune system stays activated. Your symptoms persist.
EDTA nasal spray addresses this. EDTA chelates (binds to) calcium, which is the structural "glue" holding bacterial biofilms together. When the biofilms break down, bacteria are exposed to your immune system and can finally be cleared.
We're evicting the squatters that moved in while your immune system was compromised.
Note: EDTA is FDA-approved for other uses but is ordered off-label for this application. MoldCo can test for suspected MARCoNS when requested by members.
See if the Shoemaker Protocol approach is right for you
MoldCo's clinicians are trained in Dr. Shoemaker's methods and can guide you through each phase.
Phase 3: Repair (restoring immune balance with VIP)
VIP (Vasoactive Intestinal Peptide) is a neuropeptide your body naturally produces. In patients with mold-related illness, VIP levels are often suppressed. This affects metabolism, immune regulation, and brain function.
VIP therapy restores what chronic inflammation stripped away. It dials down the inflammatory signals (cytokines) that have been running hot, rebuilds the communication between your brain and immune system, and helps normalize your hormonal rhythms.
After removing what was harming you, this phase helps your body remember how to function normally again.
You take VIP as a nasal spray (prescribed off-label for this use), supervised by your clinician. This phase represents the body finally getting to heal rather than just survive. Research has shown VIP therapy can correct inflammatory markers and restore function in patients who've completed the earlier phases.
Common mistakes to avoid
Treating out of sequence
Each phase exists for a reason. Trying to address bacterial colonies (Phase 2) before reducing toxin load (Phase 1) means your immune system is still overwhelmed. Jumping to VIP therapy before clearing MARCoNS leaves inflammation triggers in place.
The sequence matters.
Waiting for the perfect environment before starting
Many people put off treatment until they can move to a mold-free home. But finding clean housing can take months or longer.
"The longer you stay, the more you normalize this new state of being. And the sicker you get, and the longer you stay this way, the more ... that will just become 'who you are.'" — Reddit user
Treatment can begin during exposure. It's not ideal, but progress is possible. Don't let perfect be the enemy of good.
Expecting immediate results
Mold-related illness often builds up over years. Treatment takes months, not days. The typical protocol duration is 6-12 months, with most patients completing in 6-9 months.
"Not able to leave, yet. Have been spiraling out of control lately with negative behaviors. I know much of it, if not all, is from a dysregulated nervous system." — Reddit user
Patience is part of the protocol.
Stopping early
Some patients feel better after a few weeks on binders and assume they're done. But partial treatment often leads to relapse. Completing all phases gives you the best chance of lasting improvement.
Before you start: what to expect
Labs are optional, not required. Your clinician bases treatment on your exposure history plus symptoms. If you know you've been in a water-damaged building and you're experiencing multiple symptoms across different body systems (fatigue, brain fog, joint pain, gut issues, etc.), that's often enough information to begin.
Expect a 6-12 month journey. Most patients who follow the protocol consistently report improvements within the first 8 weeks, with continued progress as they move through each phase.
The protocol is sequenced, but your experience will be individualized. Your clinician will guide timing based on your response to each phase.
Frequently asked questions
How long does the Shoemaker Protocol take?
Most patients complete treatment in 6-12 months, with the majority finishing in 6-9 months. The timeline depends on how long you've been sick, the severity of exposure, and how your body responds to each phase.
Can I start treatment if I'm still in a moldy environment?
Yes. While leaving the exposure source is ideal, treatment can begin even during ongoing exposure. Binders can help reduce toxin burden while you work on your housing situation. Don't delay treatment indefinitely waiting for perfect conditions.
Why aren't more doctors familiar with this protocol?
Institutions take time to adopt evidence. Out of 114 epidemiological studies on chronic indoor dampness and microbial growth exposure, 112 (98.2%) report adverse human health effects. The research exists. Widespread adoption takes longer.
Many doctors also lack training in environmental illness. Medical schools focus on acute conditions, not chronic multi-system illness triggered by environmental exposures.
What if others in my home aren't sick? Does that mean mold isn't my problem?
Not at all. About 24% of the population carries HLA genes that make them susceptible to mold-related illness. The other 76% can be exposed to the same environment and clear the toxins normally.
Add in different exposure durations, stress levels, prior infections, and individual biology, and it makes sense why one person gets sick while others don't. This doesn't invalidate your illness.
As one patient described their experience:
"I unknowingly lived in mold for ~5 years. During that time, my health deteriorated to a point where I honestly almost died... For years I had labile blood pressure with regular hypertensive crises, severe systemic pain (including constant head pain), hallucinations..." — Reddit user
Is this just chronic fatigue or anxiety?
It's a fair question. Mold-related illness is often misdiagnosed as chronic fatigue syndrome, fibromyalgia, anxiety, IBS, or depression.
The difference: mold-related illness shows a distinct immune pattern. When MMP-9 and TGF-B1 are elevated together while MSH is suppressed, that three-point immune fingerprint is vanishingly rare outside mold-related illness. Lots of diseases can raise one marker. This combination points to a specific problem.
"I started having joint pain, insomnia, shortness of breath, color distortion, bloating like pregnancy, tunnel view, suicidal thoughts... could not finish a sentence, could not remember anything, cannot concentrate..." — Reddit user
What results can I expect?
Results vary by individual. When patients follow the protocol consistently, most report improvements in the first 8 weeks. Complete improvement takes longer and requires finishing all phases.
Research from Dr. Shoemaker's work shows VIP therapy can correct inflammatory markers and restore function in patients who've completed the earlier treatment phases. MoldCo's approach is guided by this research.
Taking the next step
You've been searching for answers. Maybe for months, maybe for years. The Shoemaker Protocol offers a structured, evidence-based path forward.
MoldCo provides virtual-first care guided by the Shoemaker Protocol. One platform for labs, treatment, and care navigation. Clinicians trained in Dr. Shoemaker's methods. Treatment that can start based on your exposure and symptoms.
If you're ready to stop wondering and start treating, we're here to help.
Any health-related claims made on this site have not been evaluated by the Food and Drug Administration (FDA). The information provided on this site is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. MoldCo assumes no responsibility or liability for any errors or omissions in the content of the references, nor for any actions taken in reliance thereon.